Downloads for Veterinary Professionals

  • Pharmacology of pain: Librela (bedinvetmab).

    Thursday 25th February 2021 was a landmark day!

    Three of my patients with OA were injected with their first dose of LibrelaTM (bedinvetmab), monoclonal antibodies to canine Nerve Growth Factor (NGF). All three are unable to take NSAID and this offers them the opportunity for  significant pain relief.

    Please click the title line for a Zoetis Technical PDF.

    Further information is also available at

  • Do NSAIDs inhibit bone healing?

    A recent webinar discussion suggested NSAIDs inhibited bone healing.

    Please click on the title above for more information.

    Short answer – any preclinical data has very limited significance to veterinary clinical work.

  • ‘Regenerative medicine’, knowns and unknowns

    There are many claims made for ‘regenerative medicine’, raising just as many questions. Does treatment with stem cells:

    • Regenerate articular cartilage in joints affected with advanced OA?
    • Heal damaged cruciate ligaments?
    • Treat DLSS?

    This paper by Bogers (2018) looks at the evidence for some of these claims.

  • Pharmacology of pain - Solensia

    Solensia (frunevetmab) is a product containing feline-specific monoclonal antibodies to Nerve Growth Factor (NGF).

    Solensia offers the prospect of effective osteoarthritis (OA)-related pain control for cats who are unable to take the other licenced NSAID products.

    Zoetis have produced an informative website, have a look at The New Science of Feline OA Pain. Here you will find technical information about Solensia and also client materials, such as a cat-specific OA-related pain questionnaire.

    24th June 2021

  • Pharmacology of pain - CRI Calculator

    Constant Rate Infusions (CRI) are used mainly in acute pain management, but also can be a useful tool for managing acute episodes in animals with chronic conditions.

    The International Veterinary Academy of Pain Management has published a CRI Calculator on their website.

    • Clinicians should ensure the final results are correct before relying on this calculator.
    • The site provides access to references.
    • The results can be personalised for each animal and printed off for use in the clinic.
  • Sensitivity, Specificity and Predictive Value

    The Predictive Value (PV) of a laboratory test result is determined by the sensitivity and specificity of the test itself and the prevalence of disease in a population. The PV of lab tests has recently been discussed in testing for disease in people and animals.

    There are online calculators which provide an instant answer.

    This  Nomogram – Sherwin Hall MRCVS developed by the late Sherwin Hall MRCVS (Hall & Richards 1984), allows an appreciation for how these variables affect the PV. Please print in Landscape format.

    For example,

    • With 95% sensitivity & 95% specificity, and prevalence of 0.05 (screening a general population), the PV is 0.5 – you would be as well flipping a coin.
    • With 95% sensitivity & 95% specificity, and prevalence of 0.5 (screening a population with symptoms of the disease), the PV is 0.95 – at which point one could be certain 95% of the results would be correct.
  • Any suggestions?

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